The 11th Annual UCLA Heart Failure Symposium 2023 will discuss general heart failure treatment options, including short- and long-term mechanical circulatory support therapy, heart transplantation, pulmonary hypertension management, high-risk percutaneous and structural interventions, and complex congenital heart disease management. Also, it will emphasize the need for developing networks linking academic centers with community physicians to manage these patients through the evolution of their disease pre- and post-advanced cardiac intervention. Last, it will address heart failure therapies in cardio-oncology, amyloidosis and new medication updates, as well as patient and care-provider’s specific needs and perspectives.